Article
A general efficient and flexible approach for genome-wide association analyses of imputed genotypes in family-based designs.
Genetic epidemiology - 1 Sept 2014
Cobat Aurélie, Abel Laurent, Alcaïs Alexandre, Schurr Erwin
Abstract excerpt
Genotype imputation is a critical technique for following up genome-wide association studies. Efficient methods are available for dealing with the probabilistic nature of imputed single nucleotide polymorphisms (SNPs) in population-based designs, but not for family-based studies. We have developed a new analytical approach (FBATdosage), using imputed allele dosage in the general framework of family-based...
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