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Article

Gene-based interaction analysis by incorporating external linkage disequilibrium information.

European journal of human genetics : EJHG - 1 Feb 2011

He Jing, Wang Kai, Edmondson Andrew C, Rader Daniel J, Li Chun, Li Mingyao

Abstract excerpt

Gene-gene interactions have an important role in complex human diseases. Detection of gene-gene interactions has long been a challenge due to their complexity. The standard method aiming at detecting SNP-SNP interactions may be inadequate as it does not model linkage disequilibrium (LD) among SNPs in each gene and may lose power due to a large number of comparisons. To improve power, we propose a principal...

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Identifiers

PMID: 20924406
DOI: 10.1038/ejhg.2010.164
PMCID: PMC3025792

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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