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Article

Suboptimal B-cell antigen receptor signaling activity in vivo elicits germinal center counterselection mechanisms.

European journal of immunology - 1 Feb 2015

Königsberger Sebastian, Weis Vanessa, Prodöhl Jan, Stehling Martin, Hobeika Elias, Reth Michael, Kiefer Friedemann

Abstract excerpt

Syk and Zap-70 constitute a closely related nonreceptor protein tyrosine kinase family, of which both members are functionally indispensable for conferring their respective antigen receptors with enzymatic activity. In this study, we analyze the impact of altering BCR signaling output on B-cell germinal center (GC) fate selection by constitutive, as well as inducible, monoallelic Syk kinase loss in the presence...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25382621
DOI: 10.1002/eji.201444538

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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