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Article

Altered BCR signalling quality predisposes to autoimmune disease and a pre-diabetic state.

The EMBO journal - 1 Aug 2012

Königsberger Sebastian, Prodöhl Jan, Stegner David, Weis Vanessa, Andreas Martin, Stehling Martin, Schumacher Theresa, Böhmer Ruben, Thielmann Ina, van Eeuwijk Judith M M, Nieswandt Bernhard, Kiefer Friedemann

Abstract excerpt

The spleen tyrosine kinase family members Syk and Zap-70 are pivotal signal transducers downstream of antigen receptors and exhibit overlapping expression patterns at early lymphocytic developmental stages. To assess their differential kinase fitness in vivo, we generated mice, which carry a Zap-70 cDNA knock-in controlled by intrinsic Syk promoter elements that disrupts wild-type Syk expression. Kinase...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Gene Rearrangement, B-Lymphocyte

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Source

Open in PubMed Open full text

Identifiers

PMID: 22728826
DOI: 10.1038/emboj.2012.169
PMCID: PMC3411075

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Altered BCR signalling quality predisposes to autoimmune disease and a pre-diabetic state.PMID 22728826Read ↗

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