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Article

Unexpected requirement for ZAP-70 in pre-B cell development and allelic exclusion.

Immunity - 1 Apr 2003

Schweighoffer Edina, Vanes Lesley, Mathiot Anne, Nakamura Tetsuya, Tybulewicz Victor L J

Abstract excerpt

ZAP-70, a member of the Syk family of tyrosine kinases, has been reported to be expressed exclusively in T and NK cells. We show here that it is expressed throughout B cell development and that it plays a role in the transition of pro-B to pre-B cells in the bone marrow, a checkpoint controlled by signals from the pre-B cell receptor (pre-BCR), which monitors for successful rearrangement of immunoglobulin heavy...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12705855
DOI: 10.1016/s1074-7613(03)00082-7

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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