Role of Syk in B-cell development and antigen-receptor signaling.

doi:10.1073/pnas.97.4.1713

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Role of Syk in B-cell development and antigen-receptor signaling.

Proceedings of the National Academy of Sciences of the United States of America - 15 Feb 2000

Cornall R J, Cheng A M, Pawson T, Goodnow C C

Abstract excerpt

Antigen receptors (BCRs) on developing B lymphocytes play two opposing roles-promoting survival of cells that may later bind a foreign antigen and inhibiting survival of cells that bind too strongly to self-antigens. It is not known how these opposing outcomes are signaled by BCRs on immature B cells. Here we analyze the effect of a null mutation in the Syk tyrosine kinase on maturing B cells displaying a...

Topics

Animals
Antigens, CD
B-Lymphocytes
Bone Marrow
CD79 Antigens
Calcium
Enzyme Precursors
Immunoglobulin M
Intracellular Signaling Peptides and Proteins
Leukocyte Common Antigens
Mice
Mice, Inbred Strains
Mice, Transgenic
Muramidase

Source

Open in PubMed Open full text

Identifiers

PMID: 10677523
DOI: 10.1073/pnas.97.4.1713
PMCID: PMC26501

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Phosphorylation

Protein Binding

Protein-Tyrosine Kinases