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Article

Role of Syk in B-cell development and antigen-receptor signaling.

Proceedings of the National Academy of Sciences of the United States of America - 15 Feb 2000

Cornall R J, Cheng A M, Pawson T, Goodnow C C

Abstract excerpt

Antigen receptors (BCRs) on developing B lymphocytes play two opposing roles-promoting survival of cells that may later bind a foreign antigen and inhibiting survival of cells that bind too strongly to self-antigens. It is not known how these opposing outcomes are signaled by BCRs on immature B cells. Here we analyze the effect of a null mutation in the Syk tyrosine kinase on maturing B cells displaying a...

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Source

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Identifiers

PMID: 10677523
DOI: 10.1073/pnas.97.4.1713
PMCID: PMC26501

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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