Article
VEGF-targeted therapy stably modulates the glycolytic phenotype of tumor cells.
Cancer research - 1 Jan 2015
Curtarello Matteo, Zulato Elisabetta, Nardo Giorgia, Valtorta Silvia, Guzzo Giulia, Rossi Elisabetta, Esposito Giovanni, Msaki Aichi, Pastò Anna, Rasola Andrea, Persano Luca, Ciccarese Francesco, Bertorelle Roberta, Todde Sergio, Plebani Mario, Schroer Henrike, Walenta Stefan, Mueller-Klieser Wolfgang, Amadori Alberto, Moresco Rosa Maria, Indraccolo Stefano
Abstract excerpt
Anti-VEGF therapy perturbs tumor metabolism, severely impairing oxygen, glucose, and ATP levels. In this study, we investigated the effects of anti-VEGF therapy in multiple experimental tumor models that differ in their glycolytic phenotypes to gain insights into optimal modulation of the metabolic features of this therapy. Prolonged treatments induced vascular regression and necrosis in tumor xenograft models,...
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