Article
Hypoxia inducible factor-1alpha inactivation unveils a link between tumor cell metabolism and hypoxia-induced cell death.
The American journal of pathology - 1 Oct 2008
Favaro Elena, Nardo Giorgia, Persano Luca, Masiero Massimo, Moserle Lidia, Zamarchi Rita, Rossi Elisabetta, Esposito Giovanni, Plebani Mario, Sattler Ulrike, Mann Thomas, Mueller-Klieser Wolfgang, Ciminale Vincenzo, Amadori Alberto, Indraccolo Stefano
Abstract excerpt
Hypoxia and the acquisition of a glycolytic phenotype are intrinsic features of the tumor microenvironment. The hypoxia inducible factor-1alpha (HIF-1alpha) pathway is activated under hypoxic conditions and orchestrates a complex transcriptional program that enhances cell survival. Although the consequences of HIF-1alpha inactivation in cancer cells have been widely investigated, only a few studies have addressed...
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