Article
Glycolytic phenotype and AMP kinase modify the pathologic response of tumor xenografts to VEGF neutralization.
Cancer research - 15 Jun 2011
Nardo Giorgia, Favaro Elena, Curtarello Matteo, Moserle Lidia, Zulato Elisabetta, Persano Luca, Rossi Elisabetta, Esposito Giovanni, Crescenzi Marika, Casanovas Oriol, Sattler Ulrike, Mueller-Klieser Wolfgang, Biesalski Barbara, Thews Oliver, Canese Rossella, Iorio Egidio, Zanovello Paola, Amadori Alberto, Indraccolo Stefano
Abstract excerpt
VEGF antagonists are now widely used cancer therapeutics, but predictive biomarkers of response or toxicity remain unavailable. In this study, we analyzed the effects of anti-VEGF therapy on tumor metabolism and therapeutic response by using an integrated set of imaging techniques, including bioluminescence metabolic imaging, 18-fluorodeoxyglucose positron emission tomography, and MRI imaging and spectroscopy....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.