Article
Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo.
Cell metabolism - 6 Jun 2012
Marin-Valencia Isaac, Yang Chendong, Mashimo Tomoyuki, Cho Steve, Baek Hyeonman, Yang Xiao-Li, Rajagopalan Kartik N, Maddie Melissa, Vemireddy Vamsidhara, Zhao Zhenze, Cai Ling, Good Levi, Tu Benjamin P, Hatanpaa Kimmo J, Mickey Bruce E, Matés José M, Pascual Juan M, Maher Elizabeth A, Malloy Craig R, Deberardinis Ralph J, Bachoo Robert M
Abstract excerpt
Dysregulated metabolism is a hallmark of cancer cell lines, but little is known about the fate of glucose and other nutrients in tumors growing in their native microenvironment. To study tumor metabolism in vivo, we used an orthotopic mouse model of primary human glioblastoma (GBM). We infused (13)C-labeled nutrients into mice bearing three independent GBM lines, each with a distinct set of mutations. All three...
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