Article

Anaplerotic nutrient stress drives synergy of angiogenesis inhibitors with therapeutics targeting tumor metabolism

2023-05-09

Abstract excerpt

<h4>ABSTRACT</h4> Tumor angiogenesis is a cancer hallmark, and its therapeutic inhibition has provided meaningful, albeit limited, clinical benefit. While anti-angiogenesis inhibitors deprive the tumor of oxygen and essential nutrients, cancer cells activate metabolic adaptations to diminish therapeutic response. Despite these adaptations, angiogenesis inhibition incurs extensive metabolic stress, prompting us to...

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Literature Corpus work: 472e6f72-062c-5e29-a3e0-60f8697c5df6
DOI: 10.1101/2023.05.07.539744

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