Article

A tumor metabolism-angiogenesis-immune axis governs immunotherapy responses

2026-02-24

Abstract excerpt

Despite the clinical success of immunotherapy, long-lasting benefit remains restricted to a subset of patients. Tumor metabolic adaptation is emerging as a key factor limiting immunotherapy efficacy. We previously found that glycolysis-low tumor variants, compared to the parental glycolytic tumors, better respond to neoadjuvant CTLA-4 immune checkpoint blockade (ICB) therapy. Here, we investigated new rational mod...

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Literature Corpus work: 9dea7c5e-e0a3-5c45-8bf5-deb09abcc3fd
DOI: 10.64898/2026.02.23.707524

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