Article

Anaplerotic nutrient stress drives synergy of angiogenesis inhibitors with therapeutics targeting tumor metabolism

2023-06-21

Abstract excerpt

<title>Abstract</title> <p>Tumor angiogenesis is a cancer hallmark, and its therapeutic inhibition has provided meaningful, albeit limited, clinical benefit. While anti-angiogenesis inhibitors deprive the tumor of oxygen and essential nutrients, cancer cells activate metabolic adaptations to diminish therapeutic response. Despite these adaptations, angiogenesis inhibition incurs extensive metabolic stress, prompt...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e5c177dc-b815-557e-ab77-c234abf53f04
DOI: 10.21203/rs.3.rs-2987360/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Anaplerotic nutrient stress drives synergy of angiogenesis inhibitors with therapeutics targeting tumor metabolismDOI 10.21203/rs.3.rs-2987360/v1Read

Anaplerotic nutrient stress drives synergy of angiogenesis inhibitors with therapeutics targeting tumor metabolismSemantic proximity Read

Targeting Hypoxia-Driven Metabolic Reprogramming to Constrain Tumor Progression and MetastasisSemantic proximity Read

Metabolism and signaling crosstalk in glioblastoma progression and therapy resistanceSemantic proximity Read

The Glioblastoma Microenvironment: Morphology, Metabolism, and Molecular Signature of Glial Dynamics to Discover Metabolic Rewiring SequenceSemantic proximity Read

Enhanced fatty acid oxidation provides glioblastoma cells metabolic plasticity to accommodate to its dynamic nutrient microenvironment.Semantic proximity Read

Advancing glioblastoma treatment by targeting metabolismSemantic proximity Read

Adapt and conquer: Metabolic flexibility in cancer growth, invasion and evasion.Semantic proximity Read

Comprehensive Analysis of Glycolytic Enzymes as Therapeutic Targets in the Treatment of GlioblastomaSemantic proximity Read

Comprehensive Metabolic Profiling of MYC-Amplified Medulloblastoma Tumors Reveals Key Dependencies on Amino Acid, Tricarboxylic Acid and Hexosamine PathwaysSemantic proximity Read

Glioblastomas: Hijacking Metabolism to Build a Flexible Shield for Therapy ResistanceSemantic proximity Read

Angiogenesis revisited from a metabolic perspective: role and therapeutic implications of endothelial cell metabolismSemantic proximity Read

Fatal Alliance of Hypoxia-/HIF-1α-Driven Microenvironmental Traits Promoting Cancer Progression.Semantic proximity Read