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Article

Characterization of gene mutations and copy number changes in acute myeloid leukemia using a rapid target enrichment protocol.

Haematologica - 1 Feb 2015

Bolli Niccolò, Manes Nicla, McKerrell Thomas, Chi Jianxiang, Park Naomi, Gundem Gunes, Quail Michael A, Sathiaseelan Vijitha, Herman Bram, Crawley Charles, Craig Jenny I O, Conte Natalie, Grove Carolyn, Papaemmanuil Elli, Campbell Peter J, Varela Ignacio, Costeas Paul, Vassiliou George S

Abstract excerpt

Prognostic stratification is critical for making therapeutic decisions and maximizing survival of patients with acute myeloid leukemia. Advances in the genomics of acute myeloid leukemia have identified several recurrent gene mutations whose prognostic impact is being deciphered. We used HaloPlex target enrichment and Illumina-based next generation sequencing to study 24 recurrently mutated genes in 42 samples of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25381129
DOI: 10.3324/haematol.2014.113381
PMCID: PMC4803131

Genes

FLT3
NPM1
BCOR
KRAS
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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