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Article

A DNA target-enrichment approach to detect mutations, copy number changes and immunoglobulin translocations in multiple myeloma.

Blood cancer journal - 2 Sept 2016

Bolli N, Li Y, Sathiaseelan V, Raine K, Jones D, Ganly P, Cocito F, Bignell G, Chapman M A, Sperling A S, Anderson K C, Avet-Loiseau H, Minvielle S, Campbell P J, Munshi N C

Abstract excerpt

Genomic lesions are not investigated during routine diagnostic workup for multiple myeloma (MM). Cytogenetic studies are performed to assess prognosis but with limited impact on therapeutic decisions. Recently, several recurrently mutated genes have been described, but their clinical value remains to be defined. Therefore, clinical-grade strategies to investigate the genomic landscape of myeloma samples are...

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Share to DNA Copy Number Variations
Share to Gene Rearrangement, B-Lymphocyte, Heavy Chain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to High-Throughput Nucleotide Sequencing

Share to Immunoglobulin Heavy Chains

Share to Loss of Heterozygosity

Share to Multiple Myeloma

Share to Reproducibility of Results

Share to Translocation, Genetic

Source

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Identifiers

PMID: 27588520
DOI: 10.1038/bcj.2016.72
PMCID: PMC5056967

Genes

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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