Article
Analytical validation and performance characteristics of a 48-gene next-generation sequencing panel for detecting potentially actionable genomic alterations in myeloid neoplasms.
PloS one - 1 Jan 2021
Rosenthal Sun Hee, Gerasimova Anna, Ma Charles, Li Hai-Rong, Grupe Andrew, Chong Hansook, Acab Allan, Smolgovsky Alla, Owen Renius, Elzinga Christopher, Chen Rebecca, Sugganth Daniel, Freitas Tracey, Graham Jennifer, Champion Kristen, Bhattacharya Anindya, Racke Frederick, Lacbawan Felicitas
Abstract excerpt
Identification of genomic mutations by molecular testing plays an important role in diagnosis, prognosis, and treatment of myeloid neoplasms. Next-generation sequencing (NGS) is an efficient method for simultaneous detection of clinically significant genomic mutations with high sensitivity. Various NGS based in-house developed and commercial myeloid neoplasm panels have been integrated into routine clinical...
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