Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Variation in predictive ability of common genetic variants by established strata: the example of breast cancer and age.

Epidemiology (Cambridge, Mass.) - 1 Jan 2015

Aschard Hugues, Zaitlen Noah, Lindström Sara, Kraft Peter

Abstract excerpt

BACKGROUND: Recent studies of breast cancer and common genetic markers have failed to identify pervasive gene-gene and gene-environment interactions. Theoretical considerations also suggest that the contribution of modest interactions to risk discrimination in the general population is likely small. However, the clinical utility of common breast cancer risk markers may nonetheless differ across strata defined by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Factors
Share to Aged
Share to Area Under Curve

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Breast Neoplasms

Share to Case-Control Studies

Share to Gene-Environment Interaction

Share to Odds Ratio

Share to Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 25380502
DOI: 10.1097/EDE.0000000000000195
PMCID: PMC5082110

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variation in predictive ability of common genetic variants by established strata: the example of breast cancer and age.PMID 25380502Read ↗

Performance of common genetic variants in breast-cancer risk models.Semantic proximity Read ↗

Prediction of breast cancer risk based on profiling with common genetic variants.Semantic proximity Read ↗

Breast Cancer Risk Prediction Using Clinical Models and 77 Independent Risk-Associated SNPs for Women Aged Under 50 Years: Australian Breast Cancer Family Registry.Semantic proximity Read ↗

Using SNP genotypes to improve the discrimination of a simple breast cancer risk prediction model.Semantic proximity Read ↗

Discriminatory accuracy from single-nucleotide polymorphisms in models to predict breast cancer risk.Semantic proximity Read ↗

Using Breast Cancer Risk Associated Polymorphisms to Identify Women for Breast Cancer Chemoprevention.Semantic proximity Read ↗

The impact of age on genetic risk for common diseasesSemantic proximity Read ↗

Genome-based prediction of breast cancer risk in the general population: a modeling study based on meta-analyses of genetic associations.Semantic proximity Read ↗

Addition of a polygenic risk score, mammographic density, and endogenous hormones to existing breast cancer risk prediction models: A nested case-control study.Semantic proximity Read ↗

Potential usefulness of single nucleotide polymorphisms to identify persons at high cancer risk: an evaluation of seven common cancers.Semantic proximity Read ↗

Ability to predict breast cancer in Asian women using a polygenic susceptibility model.Semantic proximity Read ↗

Assessment of clinical validity of a breast cancer risk model combining genetic and clinical information.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.