Article
Genome-based prediction of breast cancer risk in the general population: a modeling study based on meta-analyses of genetic associations.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2011
van Zitteren Moniek, van der Net Jeroen B, Kundu Suman, Freedman Andrew N, van Duijn Cornelia M, Janssens A Cecile J W
Abstract excerpt
BACKGROUND: Genome-wide association studies identified novel breast cancer susceptibility variants that could be used to predict breast cancer in asymptomatic women. This review and modeling study aimed to investigate the current and potential predictive performance of genetic risk models. METHODS: Genotypes and disease status were simulated for a population of 10,000 women. Genetic risk models were constructed...
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