Article
Using SNP genotypes to improve the discrimination of a simple breast cancer risk prediction model.
Breast cancer research and treatment - 1 Jun 2013
Dite Gillian S, Mahmoodi Maryam, Bickerstaffe Adrian, Hammet Fleur, Macinnis Robert J, Tsimiklis Helen, Dowty James G, Apicella Carmel, Phillips Kelly-Anne, Giles Graham G, Southey Melissa C, Hopper John L
Abstract excerpt
It has been shown that, for women aged 50 years or older, the discriminatory accuracy of the Breast Cancer Risk Prediction Tool (BCRAT) can be modestly improved by the inclusion of information on common single nucleotide polymorphisms (SNPs) that are associated with increased breast cancer risk. We aimed to determine whether a similar improvement is seen for earlier onset disease. We used the Australian Breast...
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