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Article

Addition of a polygenic risk score, mammographic density, and endogenous hormones to existing breast cancer risk prediction models: A nested case-control study.

PLoS medicine - 1 Sept 2018

Zhang Xuehong, Rice Megan, Tworoger Shelley S, Rosner Bernard A, Eliassen A Heather, Tamimi Rulla M, Joshi Amit D, Lindstrom Sara, Qian Jing, Colditz Graham A, Willett Walter C, Kraft Peter, Hankinson Susan E

Abstract excerpt

BACKGROUND: No prior study to our knowledge has examined the joint contribution of a polygenic risk score (PRS), mammographic density (MD), and postmenopausal endogenous hormone levels-all well-confirmed risk factors for invasive breast cancer-to existing breast cancer risk prediction models. METHODS AND FINDINGS: We conducted a nested case-control study within the prospective Nurses' Health Study and Nurses'...

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Identifiers

PMID: 30180161
DOI: 10.1371/journal.pmed.1002644
PMCID: PMC6122802

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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