Article
Assessment of clinical validity of a breast cancer risk model combining genetic and clinical information.
Journal of the National Cancer Institute - 3 Nov 2010
Mealiffe Matthew E, Stokowski Renee P, Rhees Brian K, Prentice Ross L, Pettinger Mary, Hinds David A
Abstract excerpt
BACKGROUND: The Gail model is widely used for the assessment of risk of invasive breast cancer based on recognized clinical risk factors. In recent years, a substantial number of single-nucleotide polymorphisms (SNPs) associated with breast cancer risk have been identified. However, it remains unclear how to effectively integrate clinical and genetic risk factors for risk assessment. METHODS: Seven SNPs...
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