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Article

A systematic survey of an intragenic epistatic landscape.

Molecular biology and evolution - 1 Jan 2015

Bank Claudia, Hietpas Ryan T, Jensen Jeffrey D, Bolon Daniel N A

Abstract excerpt

Mutations are the source of evolutionary variation. The interactions of multiple mutations can have important effects on fitness and evolutionary trajectories. We have recently described the distribution of fitness effects of all single mutations for a nine-amino-acid region of yeast Hsp90 (Hsp82) implicated in substrate binding. Here, we report and discuss the distribution of intragenic epistatic effects within...

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Identifiers

PMID: 25371431
DOI: 10.1093/molbev/msu301
PMCID: PMC4271534

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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