Article
The Adaptive Potential of the Middle Domain of Yeast Hsp90.
Molecular biology and evolution - 23 Jan 2021
Cote-Hammarlof Pamela A, Fragata Inês, Flynn Julia, Mavor David, Zeldovich Konstantin B, Bank Claudia, Bolon Daniel N A
Abstract excerpt
The distribution of fitness effects (DFEs) of new mutations across different environments quantifies the potential for adaptation in a given environment and its cost in others. So far, results regarding the cost of adaptation across environments have been mixed, and most studies have sampled random mutations across different genes. Here, we quantify systematically how costs of adaptation vary along a large...
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