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Article

Network of epistatic interactions within a yeast snoRNA.

Science (New York, N.Y.) - 13 May 2016

Puchta Olga, Cseke Botond, Czaja Hubert, Tollervey David, Sanguinetti Guido, Kudla Grzegorz

Abstract excerpt

Epistatic interactions play a fundamental role in molecular evolution, but little is known about the spatial distribution of these interactions within genes. To systematically survey a model landscape of intragenic epistasis, we quantified the fitness of ~60,000 Saccharomyces cerevisiae strains expressing randomly mutated variants of the 333-nucleotide-long U3 small nucleolar RNA (snoRNA). The fitness effects of...

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Share to Epistasis, Genetic
Share to Gene Expression Regulation, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genes, Fungal

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Share to RNA Folding

Share to RNA, Small Nucleolar

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Source

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Identifiers

PMID: 27080103
DOI: 10.1126/science.aaf0965
PMCID: PMC5137784

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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