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Article

Latent effects of Hsp90 mutants revealed at reduced expression levels.

PLoS genetics - 1 Jun 2013

Jiang Li, Mishra Parul, Hietpas Ryan T, Zeldovich Konstantin B, Bolon Daniel N A

Abstract excerpt

In natural systems, selection acts on both protein sequence and expression level, but it is unclear how selection integrates over these two dimensions. We recently developed the EMPIRIC approach to systematically determine the fitness effects of all possible point mutants for important regions of...

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Share to Amino Acid Substitution
Share to Gene Expression Regulation, Fungal
Share to Genetic Fitness

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HSP90 Heat-Shock Proteins

Share to Point Mutation

Share to Saccharomyces cerevisiae Proteins

Share to Selection, Genetic

Share to Substrate Specificity

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Identifiers

PMID: 23825969
DOI: 10.1371/journal.pgen.1003600
PMCID: PMC3694843

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23825969-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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