Article
Statistical analysis of mutational epistasis to reveal intramolecular interaction networks in proteins.
Methods in enzymology - 1 Jan 2020
Miton Charlotte M, Chen John Z, Ost Kalum, Anderson Dave W, Tokuriki Nobuhiko
Abstract excerpt
Epistasis occurs when the combined effect of two or more mutations differs from the sum of their individual effects, and reflects molecular interactions that affect the function and fitness of a protein. Epistasis is widely recognized as a key phenomenon that drives the dynamics of evolution. It can profoundly affect our ability to understand sequence-structure-function relationships, and thus has important...
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