Article
Pervasive epistasis exposes intramolecular networks in adaptive enzyme evolution.
Nature communications - 21 Dec 2023
Buda Karol, Miton Charlotte M, Tokuriki Nobuhiko
Abstract excerpt
Enzyme evolution is characterized by constant alterations of the intramolecular residue networks supporting their functions. The rewiring of these network interactions can give rise to epistasis. As mutations accumulate, the epistasis observed across diverse genotypes may appear idiosyncratic, that is, exhibit unique effects in different genetic backgrounds. Here, we unveil a quantitative picture of the...
Topics
- Epistasis, Genetic
- Mutation
- Genotype
- Evolution, Molecular
- Genetic Fitness