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Article

Comprehensive fitness maps of Hsp90 show widespread environmental dependence.

eLife - 4 Mar 2020

Flynn Julia M, Rossouw Ammeret, Cote-Hammarlof Pamela, Fragata Inês, Mavor David, Hollins Carl, Bank Claudia, Bolon Daniel Na

Abstract excerpt

Gene-environment interactions have long been theorized to influence molecular evolution. However, the environmental dependence of most mutations remains unknown. Using deep mutational scanning, we engineered yeast with all 44,604 single codon changes encoding 14,160 amino acid variants in Hsp90 and quantified growth effects under standard conditions and under five stress conditions. To our knowledge, these are...

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Share to Genetic Fitness
Share to Adaptation, Physiological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epistasis, Genetic

Share to Gene-Environment Interaction

Share to Gene Expression Regulation, Fungal

Share to HSP90 Heat-Shock Proteins

Share to Saccharomyces cerevisiae Proteins

Share to Stress, Physiological

Source

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Identifiers

PMID: 32129763
DOI: 10.7554/eLife.53810
PMCID: PMC7069724

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