Article

A molecular portrait of microsatellite instability across multiple cancers

2016-10-04

Abstract excerpt

<h4>ABSTRACT</h4> Microsatellite instability (MSI) refers to the hypermutability of the cancer genome due to impaired DNA mismatch repair. Although MSI has been studied for decades, the large amount of sequencing data now available allows us to examine the molecular fingerprints of MSI in greater detail. Here, we analyze ~8000 exome and ~1000 whole-genome pairs across 23 cancer types. Our pan-cancer analysis reve...

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Literature Corpus work: 1a5c2211-2a25-5b3d-b589-760cfba702f2
DOI: 10.1101/079152

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