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Article

Persistence of DNMT3A mutations at long-term remission in adult patients with AML.

British journal of haematology - 1 Nov 2014

Pløen Gro G, Nederby Line, Guldberg Per, Hansen Maria, Ebbesen Lene H, Jensen Uffe Birk, Hokland Peter, Aggerholm Anni

Abstract excerpt

Mutations in DNMT3A, the gene encoding DNA methyltransferase 3 alpha, have been identified as molecular drivers in acute myeloid leukaemia (AML) with possible implications for minimal residual disease monitoring and prognosis. To further explore the utility of DNMT3A mutations as biomarkers for AML, we developed assays for sensitive detection of recurrent mutations affecting residue R882. Analysis of DNA from 298...

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Share to DNA (Cytosine-5-)-Methyltransferases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to DNA Methyltransferase 3A

Share to Drug Resistance, Neoplasm

Share to Leukemia, Myeloid, Acute

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Source

Identifiers

PMID: 25371149
DOI: 10.1111/bjh.13062

Genes

FLT3
IDH1
NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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