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Article

Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia.

Nature - 20 Feb 2014

Shlush Liran I, Zandi Sasan, Mitchell Amanda, Chen Weihsu Claire, Brandwein Joseph M, Gupta Vikas, Kennedy James A, Schimmer Aaron D, Schuh Andre C, Yee Karen W, McLeod Jessica L, Doedens Monica, Medeiros Jessie J F, Marke Rene, Kim Hyeoung Joon, Lee Kwon, McPherson John D, Hudson Thomas J, Brown Andrew M K, Yousif Fouad, Trinh Quang M, Stein Lincoln D, Minden Mark D, Wang Jean C Y, Dick John E

Abstract excerpt

In acute myeloid leukaemia (AML), the cell of origin, nature and biological consequences of initiating lesions, and order of subsequent mutations remain poorly understood, as AML is typically diagnosed without observation of a pre-leukaemic phase. Here, highly purified haematopoietic stem cells (...

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Identifiers

PMID: 24522528
DOI: 10.1038/nature13038
PMCID: PMC4991939

Genes

NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24522528-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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