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Article

TNFα shedding in mechanically stressed cardiomyocytes is mediated by Src activation of TACE.

Journal of cellular biochemistry - 1 Apr 2015

Niu Airu, Wang Bin, Li Yi-Ping

Abstract excerpt

Synthesized by the heart under hemodynamic overloading (mechanical stress), TNFα exerts complex effects on the heart -beneficial as a membrane protein and detrimental as a secreted protein, which presents a dilemma in the treatment of congestive heart failure. We postulate that by selectively blocking mechanical stress-induced cardiomyocyte secretion of TNFα, a function of TNFα converting enzyme (TACE), the...

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Source

Identifiers

PMID: 25371038
DOI: 10.1002/jcb.25006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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