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Article

Targeted overexpression of noncleavable and secreted forms of tumor necrosis factor provokes disparate cardiac phenotypes.

Circulation - 20 Jan 2004

Diwan Abhinav, Dibbs Ziad, Nemoto Shintaro, DeFreitas Gilberto, Carabello Blase A, Sivasubramanian Natarajan, Wilson Eric M, Spinale Francis G, Mann Douglas L

Abstract excerpt

BACKGROUND: Recent studies suggest that posttranslation processing or "shedding" (ie, secretion) of tumor necrosis factor (TNF) by tumor necrosis factor-alpha converting enzyme (TACE) may contribute to the left ventricular (LV) remodeling that occurs in the failing human heart. METHODS AND RESULTS: To address the functional significance of TNF shedding, we generated lines of transgenic mice with targeted...

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Source

Identifiers

PMID: 14699008
DOI: 10.1161/01.CIR.0000109642.27985.FA

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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