Article
Selective involvement of p130Cas/Crk/Pyk2/c-Src in endothelin-1-induced JNK activation.
Hypertension (Dallas, Tex. : 1979) - 1 Jun 2003
Kodama Hiroaki, Fukuda Keiichi, Takahashi Eiichi, Tahara Satoko, Tomita Yuichi, Ieda Masaki, Kimura Kensuke, Owada Koji M, Vuori Kristiina, Ogawa Satoshi
Abstract excerpt
Both integrin-based focal adhesion complexes and receptor tyrosine kinases have been proposed as scaffolds on which the G protein-coupled receptor (GPCR)-induced signaling complex might assemble. We have recently reported that Ca2+-sensitive tyrosine kinase, Pyk2, and epidermal growth factor receptor (EGFR) act as independently regulated scaffolds in cardiomyocytes. In this report, we investigated the activation...
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