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Article

Targeted overexpression of transmembrane tumor necrosis factor provokes a concentric cardiac hypertrophic phenotype.

Circulation - 26 Aug 2003

Dibbs Ziad I, Diwan Abhinav, Nemoto Shintaro, DeFreitas Gilberto, Abdellatif Maha, Carabello Blase A, Spinale Francis G, Feuerstein Giora, Sivasubramanian Natarajan, Mann Douglas L

Abstract excerpt

BACKGROUND: Tumor necrosis factor (TNF) is initially synthesized as a 26-kDa transmembrane protein that is enzymatically cleaved by TNF-alpha converting enzyme (TACE) to generate a 17-kDa form of "secreted" TNF. Whereas the effects of secreted TNF in the heart have been characterized extensively, the effects of transmembrane TNF in the heart are unknown. METHODS AND RESULTS: We generated lines of transgenic mice...

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PMID: 12912811
DOI: 10.1161/01.CIR.0000085203.46621.F4

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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