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Article

The transmembrane domain of TACE regulates protein ectodomain shedding.

Cell research - 1 Dec 2007

Li Xiaojin, Pérez Liliana, Pan Zui, Fan Huizhou

Abstract excerpt

Numerous membrane proteins are cleaved by tumor necrosis factor-alpha converting enzyme (TACE), which causes the release of their ectodomains. An ADAM (a disintegrin and metalloprotease domain) family member, TACE contains several noncatalytic domains whose roles in ectodomain shedding have yet to be fully resolved. Here, we have explored the function of the transmembrane domain (TM) of TACE by coupling molecular...

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Source

Identifiers

PMID: 18040288
DOI: 10.1038/cr.2007.98

Genes

TNF
GPI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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