Article
Constitutive activation of the SRC family kinase Hck results in spontaneous pulmonary inflammation and an enhanced innate immune response.
The Journal of experimental medicine - 2 Sept 2002
Ernst Matthias, Inglese Melissa, Scholz Glen M, Harder Kenneth W, Clay Fiona J, Bozinovski Steven, Waring Paul, Darwiche Rima, Kay Tom, Sly Peter, Collins Rachel, Turner Debra, Hibbs Margaret L, Anderson Gary P, Dunn Ashley R
Abstract excerpt
To identify the physiological role of Hck, a functionally redundant member of the Src family of tyrosine kinases expressed in myelomonocytic cells, we generated Hck(F/F) "knock-in" mice which carry a targeted tyrosine (Y) to phenylalanine (F) substitution of the COOH-terminal, negative regulatory Y(499)-residue in the Hck protein. Unlike their Hck(-/-) "loss-of-function" counterparts, Hck(F/F) "gain-of-function"...
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