Article
The tyrosine kinase Src promotes phosphorylation of the kinase TBK1 to facilitate type I interferon production after viral infection.
Science signaling - 3 Jan 2017
Li Xuelian, Yang Mingjin, Yu Zhou, Tang Songqing, Wang Lei, Cao Xuetao, Chen Taoyong
Abstract excerpt
Various pattern recognition receptors (PRRs) are activated in response to viral infection to stimulate the production of type I interferons (IFNs). However, central to the responses of all of these receptors is their activation of the kinase TBK1, which stimulates transcription by IFN regulatory factor 3 (IRF3). We investigated the mechanism by which the kinase activity of TBK1 is stimulated in response to viral...
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