Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Delta-like 1-mediated Notch signaling enhances the in vitro conversion of human memory CD4 T cells into FOXP3-expressing regulatory T cells.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2014

Mota Catarina, Nunes-Silva Vânia, Pires Ana R, Matoso Paula, Victorino Rui M M, Sousa Ana E, Caramalho Iris

Abstract excerpt

FOXP3-expressing regulatory T cells (Treg) are essential for the prevention of autoimmunity and were shown to be reduced and/or dysfunctional in several autoimmune diseases. Although Treg-based adoptive transfer represents a promising therapy, the large cell number required to achieve clinical ef...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Surface
Share to Calcium-Binding Proteins
Share to Cellular Reprogramming

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Forkhead Transcription Factors

Share to Immunologic Memory

Share to Intercellular Signaling Peptides and Proteins

Share to Receptors, Notch

Share to T-Lymphocytes, Regulatory

Source

Identifiers

PMID: 25367118
DOI: 10.4049/jimmunol.1400198

Genes

FOXP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25367118-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Delta-like 1-mediated Notch signaling enhances the in vitro conversion of human memory CD4 T cells into FOXP3-expressing regulatory T cells.PMID 25367118Read ↗

The PDL1-PD1 axis converts human TH1 cells into regulatory T cells.Semantic proximity Read ↗

PD-L1 signaling on human memory CD4+ T cells induces a regulatory phenotype.Semantic proximity Read ↗

The Yin and Yang of Type 1 Regulatory T Cells: From Discovery to Clinical Application.Semantic proximity Read ↗

Beyond FOXP3: a 20-year journey unravelling human regulatory T-cell heterogeneity.Semantic proximity Read ↗

A novel memory-like Tfh cell subset is precursor to effector Tfh cells in recall immune responses.Semantic proximity Read ↗

Revisiting regulatory T cells in type 1 diabetesSemantic proximity Read ↗

Control of peripheral tolerance by regulatory T cell-intrinsic Notch signaling.Semantic proximity Read ↗

Memory-Phenotype CD4+ T Lymphocytes: A Double-Edged Sword in Immune Responses.Semantic proximity Read ↗

The Regulatory-T-Cell Memory Phenotype: What We Know.Semantic proximity Read ↗

Gene editing to induce FOXP3 expression in human CD4+ T cells leads to a stable regulatory phenotype and function.Semantic proximity Read ↗

Phenotypic profiling of human induced regulatory T cells at early differentiation: insights into distinct immunosuppressive potential.Semantic proximity Read ↗

CD4⁺ T cells from IPEX patients convert into functional and stable regulatory T cells by FOXP3 gene transfer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.