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Article

Control of peripheral tolerance by regulatory T cell-intrinsic Notch signaling.

Nature immunology - 1 Nov 2015

Charbonnier Louis-Marie, Wang Sen, Georgiev Peter, Sefik Esen, Chatila Talal A

Abstract excerpt

Receptors of the Notch family direct the differentiation of helper T cell subsets, but their influence on regulatory T cell (T(reg) cell) responses is obscure. We found here that lineage-specific deletion of components of the Notch pathway enhanced T(reg) cell-mediated suppression of type 1 helper T cell (T(H)1 cell) responses and protected against their T(H)1 skewing and apoptosis. In contrast, expression in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26437242
DOI: 10.1038/ni.3288
PMCID: PMC4618075

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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