Article
PD-L1 signaling on human memory CD4+ T cells induces a regulatory phenotype.
PLoS biology - 1 Apr 2021
Fanelli Giorgia, Romano Marco, Nova-Lamperti Estefania, Werner Sunderland Mariana, Nerviani Alessandra, Scottà Cristiano, Bombardieri Michele, Quezada Sergio A, Sacks Steven H, Noelle Randolph J, Pitzalis Costantino, Lechler Robert I, Lombardi Giovanna, Becker Pablo D
Abstract excerpt
Programmed cell death protein 1 (PD-1) is expressed on T cells upon T cell receptor (TCR) stimulation. PD-1 ligand 1 (PD-L1) is expressed in most tumor environments, and its binding to PD-1 on T cells drives them to apoptosis or into a regulatory phenotype. The fact that PD-L1 itself is also expressed on T cells upon activation has been largely neglected. Here, we demonstrate that PD-L1 ligation on human...
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