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Article

The PDL1-PD1 axis converts human TH1 cells into regulatory T cells.

Science translational medicine - 30 Nov 2011

Amarnath Shoba, Mangus Courtney W, Wang James C M, Wei Fang, He Alice, Kapoor Veena, Foley Jason E, Massey Paul R, Felizardo Tania C, Riley James L, Levine Bruce L, June Carl H, Medin Jeffrey A, Fowler Daniel H

Abstract excerpt

Immune surveillance by T helper type 1 (T(H)1) cells is not only critical for the host response to tumors and infection, but also contributes to autoimmunity and graft-versus-host disease (GVHD) after transplantation. The inhibitory molecule programmed death ligand 1 (PDL1) has been shown to anergize human T(H)1 cells, but other mechanisms of PDL1-mediated T(H)1 inhibition such as the conversion of T(H)1 cells to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Programmed Cell Death 1 Receptor

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 11

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Identifiers

PMID: 22133721
DOI: 10.1126/scitranslmed.3003130
PMCID: PMC3235958

Genes

FOXP3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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