Article
Laminar shear stress inhibits endothelial cell metabolism via KLF2-mediated repression of PFKFB3.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2015
Doddaballapur Anuradha, Michalik Katharina M, Manavski Yosif, Lucas Tina, Houtkooper Riekelt H, You Xintian, Chen Wei, Zeiher Andreas M, Potente Michael, Dimmeler Stefanie, Boon Reinier A
Abstract excerpt
OBJECTIVE: Cellular metabolism was recently shown to regulate endothelial cell phenotype profoundly. Whether the atheroprotective biomechanical stimulus elicited by laminar shear stress modulates endothelial cell metabolism is not known. APPROACH AND RESULTS: Here, we show that laminar flow exposure reduced glucose uptake and mitochondrial content in endothelium. Shear stress-mediated reduction of endothelial...
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