Mechanotransduction of shear in the endothelium: Basic studies and clinical implications

Abstract excerpt

The endothelium plays an integral role in the development and progression of atherosclerosis. Hemodynamic forces, particularly shear stress, have a powerful influence on endothelial phenotype and function; however, there is no clear consensus on how endothelial cells sense shear. Nevertheless, multiple endothelial cell signal transduction pathways are activated when exposed to shear stress in vitro. The type of...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Antioxidant Activity and Oxidative Stress
• Share to Cardiovascular Health and Disease Prevention
• Share to Nitric Oxide and Endothelin Effects