Article
Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2.
The Journal of clinical investigation - 1 Jan 2006
Parmar Kush M, Larman H Benjamin, Dai Guohao, Zhang Yuzhi, Wang Eric T, Moorthy Sripriya N, Kratz Johannes R, Lin Zhiyong, Jain Mukesh K, Gimbrone Michael A, García-Cardeña Guillermo
Abstract excerpt
In the face of systemic risk factors, certain regions of the arterial vasculature remain relatively resistant to the development of atherosclerotic lesions. The biomechanically distinct environments in these arterial geometries exert a protective influence via certain key functions of the endothelial lining; however, the mechanisms underlying the coordinated regulation of specific mechano-activated...
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