Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impact of sequence variation in a dominant HLA-A*02-restricted epitope in hepatitis C virus on priming and cross-reactivity of CD8+ T cells.

Journal of virology - 1 Oct 2014

Ziegler Susanne, Skibbe Kathrin, Walker Andreas, Ke Xiaoyu, Heinemann Falko M, Heinold Andreas, Mok Juk Yee, van Esch Wim J E, Yang Dongliang, Wölfl Matthias, Timm Jörg

Abstract excerpt

UNLABELLED: CD8+ T cells are an essential component of successful adaptive immune responses against hepatitis C virus (HCV). A major obstacle to vaccine design against HCV is its inherent viral sequence diversity. Here, we test the hypothesis that different sequence variants of an immunodominant CD8+ T cell epitope, all binding with high affinity to HLA class I, target different T cell receptor repertoires and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Viral
Share to CD8-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cross Reactions

Share to Epitopes, T-Lymphocyte

Share to HLA-A2 Antigen

Share to Immunity, Cellular

Share to Substance Abuse, Intravenous

Share to Viral Nonstructural Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 25008925
DOI: 10.1128/JVI.01590-14
PMCID: PMC4178828

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of sequence variation in a dominant HLA-A*02-restricted epitope in hepatitis C virus on priming and cross-reactivity of CD8+ T cells.PMID 25008925Read ↗

Cross-reactivity of hepatitis C virus specific vaccine-induced T cells at immunodominant epitopes.Semantic proximity Read ↗

An extensive antigenic footprint underpins immunodominant TCR adaptability against a hypervariable viral determinant.Semantic proximity Read ↗

Anti-hepatitis C virus T-cell immunity in the context of multiple exposures to the virus.Semantic proximity Read ↗

Human leukocyte antigen–associated sequence polymorphisms in hepatitis C virus reveal reproducible immune responses and constraints on viral evolution†Semantic proximity Read ↗

Differential capacity of T cell priming in naive donors of promiscuous CD4+ T cell epitopes of HCV NS3 and Core proteins.Semantic proximity Read ↗

Exploiting information inherent in binding sites of virus-specific antibodies: design of an HCV vaccine candidate cross-reactive with multiple genotypes.Semantic proximity Read ↗

Viral, HLA and T cell elements in cross-reactive immune responses to HIV-1 subtype A, CRF01_AE and CRF02_AG vaccine sequence in Ivorian blood donors.Semantic proximity Read ↗

Sequence variations in HCV core-derived epitopes alter binding of KIR2DL3 to HLA-C∗03:04 and modulate NK cell functionSemantic proximity Read ↗

Duration of Initial Viremia Modulates Functional Properties of HIV-specific T Cell ReceptorsSemantic proximity Read ↗

Cross-reactive CD4+ T cell responses towards seasonal and avian influenzaSemantic proximity Read ↗

The broad assessment of HCV genotypes 1 and 3 antigenic targets reveals limited cross-reactivity with implications for vaccine design.Semantic proximity Read ↗

Susceptibility to chronic hepatitis C virus infection is influenced by sequence differences in immunodominant CD8+ T cell epitopes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.