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Article

Coagulation-driven platelet activation reduces cholestatic liver injury and fibrosis in mice.

Journal of thrombosis and haemostasis : JTH - 1 Jan 2015

Joshi N, Kopec A K, O'Brien K M, Towery K L, Cline-Fedewa H, Williams K J, Copple B L, Flick M J, Luyendyk J P

Abstract excerpt

BACKGROUND: The coagulation cascade has been shown to participate in chronic liver injury and fibrosis, but the contribution of various thrombin targets, such as protease activated receptors (PARs) and fibrin(ogen), has not been fully described. Emerging evidence suggests that in some experimenta...

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Share to Chemical and Drug Induced Liver Injury

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25353084
DOI: 10.1111/jth.12770
PMCID: PMC4487795

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25353084-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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