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Article

Hyperreactivity of junctional adhesion molecule A-deficient platelets accelerates atherosclerosis in hyperlipidemic mice.

Circulation research - 13 Feb 2015

Karshovska Ela, Zhao Zhen, Blanchet Xavier, Schmitt Martin M N, Bidzhekov Kiril, Soehnlein Oliver, von Hundelshausen Philipp, Mattheij Nadine J, Cosemans Judith M E M, Megens Remco T A, Koeppel Thomas A, Schober Andreas, Hackeng Tilman M, Weber Christian, Koenen Rory R

Abstract excerpt

RATIONALE: Besides their essential role in hemostasis, platelets also have functions in inflammation. In platelets, junctional adhesion molecule (JAM)-A was previously identified as an inhibitor of integrin αIIbβ3-mediated outside-in signaling and its genetic knockdown resulted in hyperreactivity. OBJECTIVE: This gain-of-function was specifically exploited to investigate the role of platelet hyperreactivity in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25472975
DOI: 10.1161/CIRCRESAHA.116.304035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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