Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deficiency of alpha7 cholinergic receptors facilitates bacterial clearance in Escherichia coli peritonitis.

The Journal of infectious diseases - 1 Sept 2008

Giebelen Ilona A J, Le Moine Alain, van den Pangaart Petra S, Sadis Claude, Goldman Michel, Florquin Sandrine, van der Poll Tom

Abstract excerpt

BACKGROUND: The efferent vagus nerve can inhibit inflammation via interaction between acetylcholine and alpha7 cholinergic receptors. METHODS: To determine the role played by alpha7 receptors in antibacterial defense, peritonitis was induced in alpha7 receptor-deficient (alpha7(-/-)) and wild-type (WT) mice by intraperitoneal injection with Escherichia coli. RESULTS: At 20 h after infection, virtually all...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha7 Nicotinic Acetylcholine Receptor
Share to Escherichia coli Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neutrophils

Share to Peritoneum

Share to Peritonitis

Share to Receptors, Nicotinic

Share to Spleen

Source

Identifiers

PMID: 18627272
DOI: 10.1086/590432

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deficiency of alpha7 cholinergic receptors facilitates bacterial clearance in Escherichia coli peritonitis.PMID 18627272Read ↗

Cholinergic Polarization of Human MacrophagesSemantic proximity Read ↗

Tac1 Deficiency Reduces the Severity of Enteric Bacterial InfectionSemantic proximity Read ↗

Hematopoietic α7 nicotinic acetylcholine receptor deficiency increases inflammation and platelet activation status, but does not aggravate atherosclerosis.Semantic proximity Read ↗

TLR-4 pathway mediates the inflammatory response but not bacterial elimination in E. coli pneumonia.Semantic proximity Read ↗

Type 3 muscarinic receptors contribute to intestinal mucosal homeostasis and clearance of Nippostrongylus brasiliensis through induction of TH2 cytokines.Semantic proximity Read ↗

Inflammatory response and parasite regulation in acute toxoplasmosis: the role of P2X7 receptor in controlling virulent atypical genotype strain of Toxoplasma gondii.Semantic proximity Read ↗

Protease‐dependent excitation of nodose ganglion neurons by commensal gut bacteriaSemantic proximity Read ↗

Interleukin‐8 Receptor Deficiency Confers Susceptibility to Acute PyelonephritisSemantic proximity Read ↗

Impaired Host Defense in Mice Lacking ONZINSemantic proximity Read ↗

Escherichia coli P fimbriae utilize the Toll-like receptor 4 pathway for cell activation.Semantic proximity Read ↗

Activation of the cholinergic anti-inflammatory system by nicotine attenuates arthritis via suppression of macrophage migration.Semantic proximity Read ↗

Macrophages and glia are the dominant P2X7-expressing cell types in the gut nervous system—No evidence for the role of neuronal P2X7 receptors in colitisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.