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Article

Activation of toll-like receptor-7 exacerbates lupus nephritis by modulating regulatory T cells.

American journal of nephrology - 1 Jan 2014

Gong Li, Wang Yuanzhan, Zhou LiLi, Bai Xiaoyan, Wu Sha, Zhu Fengxin, Zhu Yu Feng

Abstract excerpt

BACKGROUND: Toll-like receptor-7 (TLR7), which recognizes viral single-stranded RNA, can trigger immune complex glomerulonephritis in experimental lupus erythematosus. However, whether it modulates dendritic cells (DCs) phenotype and regulatory T cells (Treg) function is incompletely understood. METHOD: Splenocytes and bone marrow DCs were obtained from 5- and 20-week-old female MRL(lpr/lpr) mice and C57BL/6...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25341693
DOI: 10.1159/000368204

Genes

TLR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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